CCR5 Mimicry by Sulfated Human Anti-HIV-1 Antibodies
نویسندگان
چکیده
HIV-1 envelope glycoprotein interaction with a principal coreceptor, CCR5, requires sulfated tyrosines on the CCR5 amino terminus. In this issue of Cell, Choe et al. identified tyrosine-sulfated, neutralizing antibodies against HIV-1 that apparently mimic CCR5. The results demonstrate for the first time that a natural posttranslational modification of an antibody can contribute substantially to antigen recognition.
منابع مشابه
Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4.
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عنوان ژورنال:
- Cell
دوره 114 شماره
صفحات -
تاریخ انتشار 2003